Synthesis and biological activities of truncated acridone: Structure-activity relationship studies of cytotoxic 5-hydroxy-4-quinolone

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

A series of 5-hydroxy-4-quinolone (3) and 5methoxy-4-quinolone (4) derivatives were synthesized as truncated acridone analogues and evaluated for antitumor and antiherpes activities. Among them 5-hydroxy-smethoxy-quinolone showed potent antitumor activity (ICse = 17.7 KM for HL60) which was greater than that of acronycine. 1997 Elsevier Science Ltd.

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