Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

To investigate the structure-activity relationship of 7,8-dimethoxy-2- methyl-3-(4,5-methylenedioxy-2-vinylphenyl)isoquinolin-1(2H) -one 2, diverse substituted 3-arylisoquinolines were synthesized and tested in vitro antitumor activity against five human tumor cell lines. The results showed a broad antitumor spectrum for a series of 3-arylisoquinolines.

Knowledge Graph

Similar Paper

Synthesis and biological evaluation of 3-arylisoquinolines as antitumor agents
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis of new 3-Arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity
Bioorganic & Medicinal Chemistry Letters 2003.0
Design, Synthesis and Biological Evaluation of the Novel Antitumor Agent 2-benzyl-3, 4-dihydroisoquinolin-1(2H)-one and Its Derivatives
Lecture Notes in Electrical Engineering 2014.0
Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and antitumor activity evaluation of 2-arylisoquinoline-1,3(2H,4H)-diones in vitro and in vivo
Medicinal Chemistry Research 2014.0
Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones
Bioorganic & Medicinal Chemistry Letters 1999.0
Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)
Bioorganic & Medicinal Chemistry 2008.0
Synthesis and biological activity of 2,5-diaryl-3-methylpyrimido[4,5-c]quinolin-1(2H)-one derivatives
Bioorganic & Medicinal Chemistry 2007.0
Antitumor Agents. Part 204: Synthesis and Biological Evaluation of Substituted 2-Aryl Quinazolinones
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis, antitumor activity, and structure–activity relationship of some 4H-pyrano[3,2-h]quinoline and 7H-pyrimido[4′,5′:6,5]pyrano[3,2-h]quinoline derivatives
Medicinal Chemistry Research 2013.0