Synthesis and antiviral evaluation of 4′-hydroxymethyl-2′, 3′-dideoxy-3′-thianucleosides and their cyclic monophosphates

Bioorganic & Medicinal Chemistry Letters
1997.0

Abstract

Novel 4'-hydroxymethyl-2',3'-dideoxy-3'-thianucleosides and their cyclic monophosphates have been synthesized and evaluated for anti-HIV activity. This is the first report of the use of the phosphorodiamidite methodology to prepare cyclic nucleoside monophosphates.

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