Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2′,3′-didehydro-2′,3′-dideoxyadenosine

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

Asymmetric synthesis of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine exhibited moderately potent anti-HIV (EC50 = 2.4 microM) activity in human PBM cells without cytotoxicity up to 100 microM.

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