Solid-phase synthesis of N-substituted amidinophenoxy pyridines as factor Xa inhibitors

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

An arylamidine linker has been employed for the solid-phase synthesis of N-substituted amidinoaryloxypyridine analogs 2 via nucleophilic substitution on a fluoropyridyl template. Two novel N-substituted amidinoaryloxypyridine derivatives 2a and 2b were discovered via this approach.

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