Reversal of multidrug resistance (MDR) by aspidofractinine-type indole alkaloids

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of indole alkaloids of the aspidofractinine-type was assessed for their potential in reversing MDR in vincristine-resistant KB cells. Of the compounds tested, kopsiflorine, kopsamine, pleiocarpine, 11-methoxykopsilongine, lahadinine A and N-methoxycarbonyl-11,12-methylenedioxy-delta 16,17-kopsinine were found to show appreciable activity.

DOI： 10.1016/s0960-894x(98)00486-7

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