A concise synthesis and in vitro cytotoxicity of new labdane diterpenes

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A new series of labdane-related diterpenes have been synthesized from (-)-sclareol and assayed in vitro cytotoxicity against mouse and human cancer cells. A key intermediate, homodrimane and furanolabdane derivatives show good in vitro cytotoxicity comparable to those of mitomycin C and adriamycin.

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