Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.

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