Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors
Bioorganic & Medicinal Chemistry Letters
1998.0
Abstract
The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.