Novel quinolone derivatives as potent antibacterials

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-c yclopropyl -4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram +ve organisms.

Knowledge Graph

Similar Paper

Novel quinolone derivatives as potent antibacterials
Bioorganic & Medicinal Chemistry Letters 1998.0
7-Substituted 5-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids: synthesis and biological activity of a new class of quinolone antibacterials
Journal of Medicinal Chemistry 1988.0
Synthesis and structure-activity relationships of new 7-[3-(fluoromethyl)piperazinyl]- and -(fluorohomopiperazinyl)quinolone antibacterials
Journal of Medicinal Chemistry 1990.0
Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria
Bioorganic & Medicinal Chemistry 2009.0
4-Substituted 4-(1H-1,2,3-triazol-1-yl)piperidine: Novel C7 moieties of fluoroquinolones as antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2010.0
Pyridonecarboxylic acids as antibacterial agents. Part 14. Synthesis and structure-activity relationships of 5-substituted 6,8-difluoroquinolones, including sparfloxacin, a new quinolone antibacterial agent with improved potency
Journal of Medicinal Chemistry 1990.0
Synthesis and Antibacterial Evaluation of Certain Quinolone Derivatives
Journal of Medicinal Chemistry 2001.0
Synthesis and antibacterial activity of 7-(substituted)aminomethyl quinolones
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and antibacterial activity of novel 6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-4-oxoquinoline-3-carboxylic acids bearing cyclopropane-fused 2-amino-8-azabicyclo[4.3.0]nonan-8-yl substituents at the C-7 position
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and Structure−Activity Relationships of 5-Amino-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-8-methylquinolonecarboxylic Acid Antibacterials Having Fluorinated 7-[(3R)-3-(1-Aminocyclopropan-1-yl)pyrrolidin-1-yl] Substituents
Journal of Medicinal Chemistry 2003.0