Solid phase organic synthesis of polyamine derivatives and initial biological evaluation of their antitumoral activity

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of N1-monosubstituted putrescine and spermine derivatives was synthesised using a solid phase methodology. We evaluated their cytotoxicity, calmodulin antagonism and polyamine uptake inhibition, pharmacological properties shared by some antitumoral agents.

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