Synthesis and antitumor activity of leinamycin derivatives: Modifications of C-8 hydroxy and C-9 keto groups

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.

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