Syntheses of (±)-shinflavanone and its structural analogues as potent inhibitors of bone resorption pits formation

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

The first total syntheses of (+/-)-shinflavanone and its structural analogues were achieved. (+/-)-Shinflavanone, appears to be a strong inhibitor of bone resorption pits formation by osteoclast-like cell induced by 1alpha, 25-dihydroxy vitamine D3 (IC50 = 0.70 microg/mL).

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