1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.

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