3D QSAR studies on new oxazolidinone antibacterial agents by comparative molecular field analysis

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Three-dimensional QSAR studies for two series of new oxazolidinone antibacterial agents were conducted using the comparative molecular field analysis (CoMFA). In vitro activities (MICs) of the compounds against methicillin-resistant Staphylococcus aureus 88 (MRSA 88) exhibited a strong correlation with their steric, electrostatic factors and lipophilicities.

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