Interaction of tyrosyl aryl dipeptides with S. aureus tyrosyl tRNA synthetase: Inhibition and crystal structure of a complex

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Tyrosyl aryl dipeptide inhibitors of S. aureus tyrosyl tRNA synthetase have been identified with IC50 values down to 0.5 microM. A crystal structure of the enzyme complexed to one of the inhibitors shows occupancy of the tyrosyl binding pocket coupled with inhibitor interactions to key catalytic residues.

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