In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Heteroaromatic trifluoromethyl ketones (TFMK's) showed strong inhibitory activity against Helicobacter pylori. The MIC50 observed for 2-trifluoroacetonylbenzoxazole (1) is 20-fold more active than metronidazole and is only twice as high as that of clarithromycin. The inhibitory mode of TFMK's on Hp growth was not related to inhibition of urease.

Knowledge Graph

Similar Paper

In vitro susceptibility of Helicobacter pylori to trifluoromethyl ketones
Bioorganic & Medicinal Chemistry Letters 1999.0
Synthesis and bioevaluation of novel 3,4,5-trimethoxybenzylbenzimidazole derivatives that inhibit Helicobacter pylori-induced pathogenesis in human gastric epithelial cells
European Journal of Medicinal Chemistry 2012.0
Anti-Helicobacter pyloriAgents. 3. 2-[(Arylalkyl)guanidino]-4-furylthiazoles
Journal of Medicinal Chemistry 1999.0
Anti- Helicobacter pylori agents. 2. Structure activity relationships in a new series of 2-alkylguanidino-4-furylthiazoles
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and in vitro anti-Helicobacter pylori activity of 2-[(chlorobenzyl)thio]-5-(5-nitro-2-furyl)-1,3,4-thiadiazoles
Medicinal Chemistry Research 2008.0
Anti-Helicobacter pyloriAgents. 1. 2-(Alkylguanidino)-4-furylthiazoles and Related Compounds
Journal of Medicinal Chemistry 1997.0
Synthesis and in vitro anti-Helicobacter pylori activity of N-[5-(5-nitro-2-heteroaryl)-1,3,4-thiadiazol-2-yl]thiomorpholines and related compounds
European Journal of Medicinal Chemistry 2008.0
Identification of 3′,4′,5′-trimethoxychalcone analogues as potent inhibitors of Helicobacter pylori-induced inflammation in human gastric epithelial cells
Bioorganic & Medicinal Chemistry Letters 2010.0
Structure−Activity Relationship of 2-[[(2-Pyridyl)methyl]thio]-1H- benzimidazoles as AntiHelicobacter pyloriAgents in Vitro and Evaluation of their in Vivo Efficacy
Journal of Medicinal Chemistry 1998.0
3-(Arylacetylamino)-N-methylbenzamides:  A Novel Class of Selective Anti-Helicobacter pylori Agents
Journal of Medicinal Chemistry 2001.0