Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Short-chain 3-fluoro-(dihydro)ceramide analogues are synthesized from L-serine using diethylaminosulfur trifluoride (DAST) as fluorinating agent. The apoptogenic activity of these compounds was measured in three different cell lines and compared with their hydroxylated counterparts.

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