Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

Short-chain sphinganine analogues 8, 9, 18, and 19, as well as 3-fluoro-sphingosine analogues 25 and 26 were synthesized. Their potential as sphingosine kinase inhibitors was investigated, in combination with previously synthesized sphingosine and fluorinated sphinganine analogues.

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