Ring constrained analogues of the orvinols: The furanomorphides

Bioorganic & Medicinal Chemistry Letters
1999.0

Abstract

A series of furanomorphides were synthesised as ring-constrained analogues of buprenorphine and related orvinols. Evaluation in binding and functional assays has shown that the furanomorphides have reduced efficacy at the mu opioid receptor compared to the orvinols.

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