Novel nikkomycin analogues: inhibitors of the fungal cell wall biosynthesis enzyme chitin synthase

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A series of novel nikkomycin analogue inhibitors of the chitin synthase of fungal cell wall was synthesized and evaluated for their inhibitory activities. Among them, the compound having a phenanthrene group at the terminal amino acid was found to possess strong anti-chitin synthase activity.

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