Design and synthesis of mimics of S-adenosyl-l-homocysteine as potential inhibitors of erythromycin methyltransferases

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A series of indanotriazine C-ribosides were prepared as SAH mimics, and tested for their ability to inhibit erythromycin resistance methylases Erm AM and Erm C'. A carbocyclic analogue derived from quinic acid was also synthesized and tested.

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