Cinnamaldehydes inhibit cyclin dependent kinase 4/cyclin D1

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A series of cinnamaldehydes was synthesized for the study of inhibitory activity against cyclin dependent kinases (CDKs). A couple of compounds selectively inhibited cyclin D1-CDK4 with an IC50 value of 7-18 microM.

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