Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.

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