Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V

Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V The amide hydrogen of (−)-indolactam-V and benzolactam-V8’s plays a critical role in protein kinase c binding and tumor-promoting activities Synthesis and protein kinase C binding activity of benzolactam-V7 Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexylindolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes Synthesis of the benzofuran analogue of ILV, a new protein kinase C (PKC) activator Synthesis of structural analogs of lyngbyatoxin A and their evaluation as activators of protein kinase C Modeling, Chemistry, and Biology of the Benzolactam Analogues of Indolactam V (ILV). 2. Identification of the Binding Site of the Benzolactams in the CRD2 Activator-Binding Domain of PKCδ and Discovery of an ILV Analogue of Improved Isozyme Selectivity Probing the Binding of Indolactam-V to Protein Kinase C through Site-Directed Mutagenesis and Computational Docking Simulations Novel indolocarbazole protein kinase c inhibitors with improved biochemical and physicochemical properties Inhibitors of protein kinase C. 1. 2,3-bisarylmaleimides