Antimitotic activity of moroidin, a bicyclic peptide from the seeds of Celosia argentea

Bioorganic & Medicinal Chemistry Letters
2000.0

Abstract

A unique bicyclic peptide, moroidin (1), from the seeds of Celosia argentea (Amaranthaceae) strongly inhibited the polymerization of tubulin. The stereostructure of moroidin (1) was reinvestigated by spectroscopic data, chemical degradation, and molecular dynamics simulation.

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