Thiazole analogues of the NSAID indomethacin as selective COX-2 Inhibitors

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.

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