Synthesis of N-Alkyl Substituted Indolocarbazoles as Potent Inhibitors of Human Cytomegalovirus Replication

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in cell culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC(50)=19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates.

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