Synthesis and evaluation of novel quinolinones as HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.

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