Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems

Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems Synthesis and preliminary evaluation steroidal antiestrogen–geldanamycin conjugates erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships Production of 8-Demethylgeldanamycin and 4,5-Epoxy-8-demethylgeldanamycin from a Recombinant Strain of Streptomyces hygroscopicus Production of 8-Demethylgeldanamycin and 4,5-Epoxy-8-demethylgeldanamycin from a Recombinant Strain of <i>Streptomyces </i><i>h</i><i>ygroscopicus</i> Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors Inactivation of the Carbamoyltransferase Gene Refines Post-Polyketide Synthase Modification Steps in the Biosynthesis of the Antitumor Agent Geldanamycin