A novel class of inhibitors for steroid 5α-Reductase: synthesis and evaluation of umbelliferone derivatives

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A series of umbelliferone derivatives was prepared and their 5alpha-reductase type 1 inhibitory activities were evaluated in cell culture systems. Our studies have identified a new series of potent 5alpha-reductase type 1 inhibitors and provided the basis for further development for the treatment of human endocrine disorders associated with overproduction of DHT by 5alpha-reductase type 1. The preliminary structure-activity relationship was described to elucidate the essential structural requirements.

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