Asymmetric synthesis of bb-3497—A potent peptide deformylase inhibitor

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

By screening a library of metalloenzyme inhibitors, the N-formyl-hydroxylamine derivative BB-3497 was identified as a potent inhibitor of Escherichia coli peptide deformylase with antibacterial activity both in vitro and in vivo. The homochiral synthesis of BB-3497, involving a novel asymmetric Michael addition reaction is described.

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