Synthesis and biological evaluation of novel bisindolylmaleimides that inhibit vascular endothelial cell proliferation

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A novel class of bisindolylmaleimides were synthesized and antiproliferative activities (HUVECs and three tumor cell lines) of these compounds were investigated. Two water-soluble derivatives, 10 and 12, possessing a dimethylaminoalkoxy side chain in their structure, showed interesting activity and selectivity on HUVECs proliferation.

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