N,N′-Bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

The synthesis, anti-Pneumocystis carinii activity and DNA binding properties of eight new N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines are reported. Compounds 2 and 8 were the most potent and caused about 70% inhibition of Pneumocystis carinii growth in a cell culture model at 1 microM concentrations.

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