A designed antagonist of the thyroid hormone receptor

A designed antagonist of the thyroid hormone receptor Structural Determinants of Selective Thyromimetics Rational Design and Synthesis of a Novel Thyroid Hormone Antagonist That Blocks Coactivator Recruitment Thyroid hormone analogs. Synthesis of 3'-substituted 3,5-diiodo-L-thyronines and quantitative structure-activity studies of in vitro and in vivo thyromimetic activities in rat liver and heart Characterization of thyroid hormone receptor α (TRα)-specific analogs with varying inner- and outer-ring substituents Design, synthesis, and structure–activity relationship (SAR) of N-[7-(4-hydroxyphenoxy)-6-methylindan-4-yl]malonamic acids as thyroid hormone receptor β (TRβ) selective agonists Thyroid receptor ligands. Part 8: Thyromimetics derived from N-acylated-α-amino acid derivatives displaying modulated pharmacological selectivity compared with KB-141 Thyrotropin releasing hormone analogs: A building block approach to the construction of tetracyclic peptidomimetics Thyroxine analogs. 23. Quantitative structure-activity correlation studies of in vivo and in vitro thyromimetic activities .alpha.-Methylated analogs of triiodothyroalkanoic acids: synthesis and biological activity