Design and synthesis of a novel class of histone deacetylase inhibitors

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.

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