Synthesis and biological evaluation of DNA targeting flexible side-chain substituted β-carboline derivatives

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

A series of 3-substituted-beta-carboline derivatives was synthesized from L-tryptophan. The intercalating binding mode of these compounds with DNA, the effects of the flexible alkylamine side chain on the intercalating ability and their antitumor activity were studied, which agreed well with the molecular modeling results.

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