Bicyclic nucleoside inhibitors of Varicella-Zoster virus (VZV)

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Novel bicyclic nucleoside analogues bearing long alkyl side chains are prepared and tested as inhibitors of VZV. In particular, analogues with terminal unsaturation in the side chain are reported. Whilst terminal alkenyl derivatives are potent antivirals, the corresponding terminal alkynyls are poorly active.

Knowledge Graph

Similar Paper

Bicyclic nucleoside inhibitors of Varicella-Zoster virus (VZV)
Bioorganic & Medicinal Chemistry Letters 2001.0
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain
Bioorganic & Medicinal Chemistry Letters 2000.0
Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base
Journal of Medicinal Chemistry 1999.0
Bicyclic anti-VZV nucleosides: thieno analogues bearing an alkylphenyl side chain have reduced antiviral activity
Bioorganic & Medicinal Chemistry Letters 2004.0
Bicyclic nucleoside inhibitors of Varicella–Zoster virus: The effect of branching in the p-alkylphenyl side chain
Bioorganic & Medicinal Chemistry Letters 2005.0
Highly Potent and Selective Inhibition of Varicella-Zoster Virus by Bicyclic Furopyrimidine Nucleosides Bearing an Aryl Side Chain
Journal of Medicinal Chemistry 2000.0
Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity
Bioorganic & Medicinal Chemistry Letters 2001.0
Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antiviral activity of 1-cyclobutyl-5-(2-bromovinyl)uracil nucleoside analogs and related compounds.
Journal of Medicinal Chemistry 1992.0
Synthesis and Antiviral Activity of the Carbocyclic Analogue of the Highly Potent and Selective Anti-VZV Bicyclo Furano Pyrimidines
Journal of Medicinal Chemistry 2007.0