FR131535, a novel water-soluble echinocandin-like lipopeptide: synthesis and biological properties

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

The synthesis and biological properties of a novel water-soluble echinocandin-like lipopeptide, FR131535, are described. This compound displayed potent in vitro and in vivo antifungal activities. The hemolytic activity of FR901379 was reduced by replacing the acyl side chain. This compound showed good water-solubility, comparable to the natural product FR901379.

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