Literature

Abstract

We have described compound 1 as a lead structure for a novel class of anti-malarial agents. Replacement of the 3-phenylpropionyl moiety of the lead structure 1 by a 4-propoxycinnamic acid residue resulted in a significant improvement in antimalarial activity. Compound 3q represents an important step in the development of lead structure 1 into an anti-malarial drug candidate.

DOI： 10.1016/s0960-894x(00)00684-3

Structure–activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives

Bioorganic & Medicinal Chemistry Letters 2001.0

Structure–Activity Relationships of Novel Anti-Malarial Agents. Part 3: N-(4-Acylamino-3-benzoylphenyl)-4-propoxycinnamic Acid Amides

Bioorganic & Medicinal Chemistry Letters 2002.0

Structure–Activity relationships of novel anti-malarial agents. Part 6: N-(4-Arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

Bioorganic & Medicinal Chemistry Letters 2003.0

Structure–Activity relationships of novel anti-Malarial agents: Part 5. N-(4-acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic acid amides

Bioorganic & Medicinal Chemistry Letters 2003.0

Structure–Activity relationships of novel anti-Malarial agents. Part 4: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides

Bioorganic & Medicinal Chemistry Letters 2002.0

Design, synthesis and biological evaluation of some novel 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones as antimalarial agents