β-d-Glycosylamidines

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Beta-D-glycosylamidines, in which a glycon is connected via an N-glycoside linkage with a substituted amidine (aglycon), were synthesized in two steps from the corresponding sugars and served as stable and potent beta-glycosidase inhibitors with high selectivity according to the glycon- and alpha, beta-specificities of the enzymes.

Knowledge Graph

Similar Paper

β-d-Glycosylamidines
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis, computational study and glycosidase inhibitory activity of polyhydroxylated conidine alkaloids—a bicyclic iminosugar
Organic & Biomolecular Chemistry 2010.0
Synthesis of 5a-carba-hexopyranoses and hexopyranosylamines, as well as 5a,5a′-dicarbadisaccharides, from 3,8-dioxatricyclo[4.2.1.02,4]nonan-9-ol: glycosidase inhibitory activity of N-substituted 5a-carba-β-gluco- and β-galactopyranosylamines, and derivatives thereof
Bioorganic & Medicinal Chemistry Letters 2004.0
The Interaction of Anhydroalditols with Sweet-Almond β-glucosidase and Escherichia coli β-galactosidase: implications for the design of potent glycosidase inhibitors
Bioorganic & Medicinal Chemistry Letters 1991.0
Synthesis of anomeric 1,5-anhydrosugars as conformationally locked selective α-mannosidase inhibitors
Bioorganic & Medicinal Chemistry 2011.0
Synthesis and α-Glucosidase II inhibitory activity of valienamine pseudodisaccharides relevant to N-glycan biosynthesis
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis of new (difluoromethylphosphono)azadisaccharides designed as bisubstrate analogue inhibitors for GlcNAc:β-1,4 glycosyltransferases
Bioorganic & Medicinal Chemistry Letters 2000.0
Novel, lipophilic derivatives of 2,5-dideoxy-2,5-imino-d-mannitol (DMDP) are powerful β-glucosidase inhibitors
Bioorganic & Medicinal Chemistry Letters 2001.0
Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors
Bioorganic & Medicinal Chemistry Letters 2008.0
Synthesis and α-glucosidase inhibitory activity evaluation of N-substituted aminomethyl-β-d-glucopyranosides
Bioorganic & Medicinal Chemistry 2013.0