3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)

Bioorganic & Medicinal Chemistry Letters
2001.0

Abstract

Potent 3-anilino-4-arylmaleimide glycogen synthase kinase-3 (GSK-3) inhibitors have been prepared using automated array methodology. A number of these are highly selective, having little inhibitory potency against more than 20 other protein kinases.

Knowledge Graph

Similar Paper

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3)
Bioorganic & Medicinal Chemistry Letters 2001.0
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3
Bioorganic & Medicinal Chemistry Letters 2003.0
Substituted 3-Imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino- [6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as Highly Selective and Potent Inhibitors of Glycogen Synthase Kinase-3
Journal of Medicinal Chemistry 2004.0
From a Natural Product Lead to the Identification of Potent and Selective Benzofuran-3-yl-(indol-3-yl)maleimides as Glycogen Synthase Kinase 3β Inhibitors That Suppress Proliferation and Survival of Pancreatic Cancer Cells
Journal of Medicinal Chemistry 2009.0
Novel 8-arylated purines as inhibitors of glycogen synthase kinase
European Journal of Medicinal Chemistry 2010.0
Design, synthesis and evaluation of 7-azaindazolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors
European Journal of Medicinal Chemistry 2013.0
Synthesis and biological evaluation of novel 4-azaindolyl-indolyl-maleimides as glycogen synthase kinase-3β (GSK-3β) inhibitors
Bioorganic & Medicinal Chemistry 2009.0
Discovery of potent and bioavailable GSK-3β inhibitors
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and in Vitro Characterization of 1-(4-Aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic Acid Derivatives. A New Class of Selective GSK-3 Inhibitors
Journal of Medicinal Chemistry 2003.0
Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3β inhibitors: A critical review
European Journal of Medicinal Chemistry 2019.0