Synthesis and cytotoxicity of 2α-amido docetaxel analogues

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

Various 2-amido docetaxel analogues were prepared and evaluated for their cytotoxicities. Among them, m-methoxy and m-chlorobenzoylamido analogues were most active but not superior to docetaxel and paclitaxel, and D-seco analogues inactive. Change of 2-benzoate to 2-benzamide may not improve their activities to drug-resistant cell lines.

Knowledge Graph

Similar Paper