Synthesis of novel furo, thieno, and benzazetoazepines and evaluation of their cytotoxicity

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

We report the regio- and stereoselective synthesis of a novel cis-C(3)N-C(4)X-C(6)N series (X=O, S, and C(2)) from cyclic ketones. The cytotoxic activity of the new compounds was studied in five cell lines; the observed activities were in accordance with the concept of bioisosteric replacement.

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