Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure–activity relationship

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

In our endeavor to design and synthesize novel anticancer agents, a new series of indoloquinazoline compounds were prepared and tested initially for anticancer activity in vitro against a panel of human cancer cell lines. Most of these compounds exhibited cytotoxic activity in in vitro screens. Compounds were selected and further evaluated using a modified Hollow Fiber Assay for their preliminary in vivo activity against 12 cell lines implanted in the subcutaneous and intraperitoneal compartments in mice. The results indicate that these compounds may constitute a new class of anticancer agents.

Knowledge Graph

Similar Paper

Novel indolo[2,1-b]quinazoline analogues as cytostatic agents: synthesis, biological evaluation and structure–activity relationship
Bioorganic & Medicinal Chemistry Letters 2002.0
Novel 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues as cytotoxic agents
Bioorganic & Medicinal Chemistry Letters 2003.0
Novel substituted hydrazono indolo[2,1- b ]quinazoline-6,12-dione analogues as cytostatic agents: Synthesis, crystal structure, biological evaluation and molecular docking studies
Bioorganic & Medicinal Chemistry Letters 2016.0
Indolylmethylene benzo[h]thiazolo[2,3-b]quinazolinones: Synthesis, characterization and evaluation of anticancer and antimicrobial activities
Bioorganic & Medicinal Chemistry Letters 2014.0
Synthesis and biological evaluation of 1-(4′-Indolyl and 6′-Quinolinyl) indoles as a new class of potent anticancer agents
European Journal of Medicinal Chemistry 2011.0
Antitumor Activity of Bis-indole Derivatives
Journal of Medicinal Chemistry 2008.0
Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives
Medicinal Chemistry Research 2013.0
Synthesis and biological evaluation of novel 2-(2-arylmethylene)hydrazinyl-4-aminoquinazoline derivatives as potent antitumor agents
European Journal of Medicinal Chemistry 2012.0
Synthesis and anti-breast cancer activity of new indolylquinone derivatives
European Journal of Medicinal Chemistry 2012.0
The synthesis of indolo[2,3-b]quinoline derivatives with a guanidine group: Highly selective cytotoxic agents
European Journal of Medicinal Chemistry 2015.0