Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent gram-positive and gram-negative antibacterial agents

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

3,6-Ketals of 15-membered azalide pseudoaglycones are a novel series of macrolide antibiotics. The aromatic derivatives of the azalide 3,6-ketals demonstrated potent antibacterial activities against both Gram-positive and Gram-negative bacteria.

Knowledge Graph

Similar Paper

Synthesis and SAR of azalide 3,6-ketal aromatic derivatives as potent gram-positive and gram-negative antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as ‘11a-azalides’
Bioorganic & Medicinal Chemistry 2012.0
Novel azalides derived from 16-membered macrolides. III. Azalides modified at the C-15 and 4″ positions: Improved antibacterial activities
Bioorganic & Medicinal Chemistry 2010.0
Synthesis and Antibacterial Activity of a Novel Class of 15-Membered Macrolide Antibiotics, “11a-Azalides”
ACS Medicinal Chemistry Letters 2011.0
Novel 9a-carbamoyl- and 9a-thiocarbamoyl-3-decladinosyl-6-hydroxy and 6-methoxy derivatives of 15-membered macrolides
Bioorganic & Medicinal Chemistry 2007.0
Synthesis and antibacterial activity of O-methyl derivatives of azalide antibiotics: II. 6-OMe derivatives VIA clarithromycin
Bioorganic & Medicinal Chemistry Letters 1998.0
Synthesis and antibacterial activity of 6-O-heteroarylcarbamoyl-11,12-lactoketolides
Bioorganic & Medicinal Chemistry Letters 2006.0
Synthesis and antibacterial activity of derivatives of 6-O-allylic acylides
Bioorganic & Medicinal Chemistry Letters 2007.0
Assessment of the biological value of the 11-hydroxy group of the azalides.
Bioorganic & Medicinal Chemistry Letters 1993.0
Synthesis and Antibacterial Activity of Acylides (3-O-Acyl-erythromycin Derivatives):  A Novel Class of Macrolide Antibiotics
Journal of Medicinal Chemistry 2001.0