Synthesis and evaluation of water-Soluble paclitaxel prodrugs

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A series of water-soluble 2'-paclitaxel prodrugs were synthesized by attaching paclitaxel to polyethylene glycol (PEG) through amino acid spacers. The prodrugs showed highly improved water solubility, enhanced in vitro cytotoxicity and in vivo antitumor activity compared with the native drug, paclitaxel.

DOI： 10.1016/s0960-894x(02)00694-7

Knowledge Graph

Similar Paper

Synthesis and evaluation of water-Soluble paclitaxel prodrugs
Bioorganic & Medicinal Chemistry Letters 2002.0
Water-soluble prodrugs of paclitaxel containing self-immolative disulfide linkers
Bioorganic & Medicinal Chemistry Letters 2015.0
Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity
Bioorganic & Medicinal Chemistry Letters 2016.0
Synthesis and Biological Evaluation of 2‘-Carbamate-Linked and 2‘-Carbonate-Linked Prodrugs of Paclitaxel:  Selective Activation by the Tumor-Associated Protease Plasmin
Journal of Medicinal Chemistry 2000.0
Modulating paclitaxel bioavailability for targeting prostate cancer
Bioorganic & Medicinal Chemistry 2007.0
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin
Bioorganic & Medicinal Chemistry Letters 2006.0
Highly water soluble taxol derivatives: 2′-polyethyleneglycol esters as potential prodrugs
Bioorganic & Medicinal Chemistry Letters 1994.0
Synthesis and In vitro efficacy of acid-Sensitive poly(ethylene glycol) paclitaxel conjugates
Bioorganic & Medicinal Chemistry Letters 2003.0
Inclusion Complexation and Solubilization of Paclitaxel by Bridged Bis(β-cyclodextrin)s Containing a Tetraethylenepentaamino Spacer
Journal of Medicinal Chemistry 2003.0
A micellar prodrug of paclitaxel conjugated to cyclotriphosphazene
Bioorganic & Medicinal Chemistry Letters 2008.0