Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

The first example of dual inhibitors for matrix metalloproteinase (MMP) and cathepsin is described. An appropriate alignment of peptide-parts and two different specific functional groups in one molecule led to the discovery of a potent dual inhibitor (3a).

Knowledge Graph

Similar Paper

Design and synthesis of dual inhibitors for matrix metalloproteinase and cathepsin
Bioorganic & Medicinal Chemistry Letters 2002.0
Dual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate−Benzenesulfonamide Conjugates
Journal of Medicinal Chemistry 2008.0
Multitargeting application of proline-derived peptidomimetics addressing cancer-related human matrix metalloproteinase 9 and carbonic anhydrase II
European Journal of Medicinal Chemistry 2021.0
Carbonic anhydrase and matrix metalloproteinase inhibitors. Inhibition of human tumor-associated isozymes IX and cytosolic isozyme I and II with sulfonylated hydroxamates
Bioorganic & Medicinal Chemistry 2007.0
Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L
Bioorganic & Medicinal Chemistry Letters 1995.0
New .alpha.-Thiol Dipeptide Dual Inhibitors of Angiotensin-I-Converting Enzyme and Neutral Endopeptidase EC 3.4.24.11
Journal of Medicinal Chemistry 1995.0
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors
Bioorganic & Medicinal Chemistry Letters 2014.0
Novel 3-galloylamido-N′-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors
Bioorganic & Medicinal Chemistry Letters 2007.0
Design, synthesis and preliminary evaluation of α-sulfonyl γ-(glycinyl-amino)proline peptidomimetics as matrix metalloproteinase inhibitors
Bioorganic & Medicinal Chemistry 2014.0
Synthesis and structure activity relationships of novel small molecule cathepsin D inhibitors
Bioorganic & Medicinal Chemistry Letters 1999.0