Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

The synthesis, antibacterial activity and DHP-susceptibility of a series of novel carbapenems, directly linked with heterocyclic moiety are described. Especially, the compounds linked pyrrolidine-carbapenem exhibited to have a good antibacterial activity against Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa to maintain a good stability towards DHP-I.

Knowledge Graph

Similar Paper

Synthesis and antibacterial evaluation of novel 2-[N-Imidoylpyrrolidinyl] carbapenems
Bioorganic & Medicinal Chemistry Letters 2002.0
Synthesis and biological activity of 1β-methyl-2-[5′-isoxazoloethenylpyrrolidin-3′-ylthio]carbapenems
Bioorganic & Medicinal Chemistry Letters 2000.0
Synthesis and biological activity of novel 1β-Methylcarbapenems with oxyiminopyrrolidinylamide moiety
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antibacterial activity of new carbapenems containing isoxazole moiety
Bioorganic & Medicinal Chemistry Letters 2000.0
Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems
Bioorganic & Medicinal Chemistry 2007.0
Synthesis and biological evaluation of novel 1β-methylcarbapenems with isothiazoloethenyl side chains
Bioorganic & Medicinal Chemistry Letters 2003.0
The synthesis and antibacterial activity of 2-carbolinyl-carbapenems: potent anti-MRSA/MRCNS agents
Bioorganic & Medicinal Chemistry Letters 1995.0
Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds
European Journal of Medicinal Chemistry 2007.0
Synthesis and biological evaluation of novel 1β-methylcarbapenems having a new moiety at C-2
Bioorganic & Medicinal Chemistry Letters 1999.0
Novel 1β-methylcarbapenems with isoxazoloethenyl moieties containing carboxylic acid sodium salt
Bioorganic & Medicinal Chemistry Letters 2005.0