Synthesis of an α-Aminophosphonate Nucleoside as an Inhibitor of S-Adenosyl-l-Homocysteine Hydrolase

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

A phosphonic acid analogue of S-adenosyl-L-homocysteine was prepared by a novel method and the epimeric mixture separated. Preliminary studies indicate that each epimer causes time-dependent inactivation of S-adenosyl-L-homocysteine hydrolase, however each presented distinct kinetic characteristics.

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