Design, synthesis and bioactivity evaluation of tribactam β lactamase inhibitors

Bioorganic & Medicinal Chemistry Letters
2002.0

Abstract

Known carbapenem compounds with inhibitory effect towards beta-lactamase enzymes are formed from bicyclical beta lactam structural scaffolds. On the basis of results from theoretical computational methods and molecular modelling we have designed and developed a synthetic route towards novel, biologically active tricyclic derivatives of carbapenems.

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